Diablo 4 Neo

Neo Rune is a Rare Rune of Ritual in Diablo IV: Vessel of Hatred. It generates Offering when you deal damage after avoiding all health damage for 5 seconds. The effect resets if you become Invulnerable. When paired with a Rune of Invocation, it forms a Runeword that can be socketed into dual-socket gear. Neo Rune is ideal for evasive builds, ranged combatants, and players who excel at avoiding damage.

“The best defense is not armor—it is absence."

Neo Rune Features

• Rune Type: Ritual | Rarity: Rare

• Gain: 300 Offering

• Condition: Deal damage after not taking any health damage for 5 seconds (resets if Invulnerable)

• Runeword Mechanic: Link with a Rune of Invocation in equipment with two Sockets to form a Runeword Only two Runewords may be active at a time

• Required Level: 68

How to Get Neo Rune

• Unlock Requirement: Complete the Fundament of Faith quest to access the Rune system

• Drop Sources:

  • Elite enemies in high-density areas (e.g. The Pit, Kurast Undercity)

  • Major campaign bosses in Vessel of Hatred

  • Whisper Caches from the Tree of Whispers

  • First-time Stronghold completions

  • Tribute of Harmony (guaranteed Rune drop)

• Crafting Option:

  • Combine 3 Ritual Runes of the same type at the Jeweler for a random Ritual Rune

  • Neo Rune may be obtained this way

• Trade Option:

  • Can be traded with other players via in-game trade interface

  • Coordinate via chat to specify the rune you want

• Expansion Requirement: Only available to players who own the Vessel of Hatred expansion

Why Neo Rune Is So Powerful

• Evasion-Based Trigger: Rewards clean play and ranged positioning

• High Offering Yield: Grants 300 Offering per trigger—ideal for mid-to-high cost Invocations

• Runeword Synergy: Pairs well with Invocation Runes that scale with Offering or uptime

• PvE & PvP Utility: Excellent for ranged builds, stealth setups, and PvP duels

• Overflow Potential: Enables powerful Invocation chains with minimal risk

Runewords That Use Neo Rune

• Neo Rune + Ohm Rune Avoid damage for 5s → deal damage → generate 300 Offering → trigger War Cry

• Neo Rune + Vex Rune Avoid damage for 5s → deal damage → generate 300 Offering → gain +1–3 to all Skills

• Neo Rune + Xan Rune Avoid damage for 5s → deal damage → generate 300 Offering → next attack Crits and Overpowers

• Neo Rune + Zec Rune Avoid damage for 5s → deal damage → generate 300 Offering → reduce Ultimate Cooldown

• Neo Rune + Tzic Rune Avoid damage for 5s → deal damage → generate 300 Offering → trigger Concussive Stomp

• Neo Rune + Gar Rune Avoid damage for 5s → deal damage → generate 300 Offering → gain +2.5% Crit Chance (stacking)

• Neo Rune + Jah Rune Avoid damage for 5s → deal damage → generate 300 Offering → replace next Evade with Teleport

• Neo Rune + Wat Rune Avoid damage for 5s → deal damage → generate 300 Offering → trigger Horrid Decrepify

• Neo Rune + Qua Rune Avoid damage for 5s → deal damage → generate 300 Offering → gain Movement Speed

• Neo Rune + Lum Rune Avoid damage for 5s → deal damage → generate 300 Offering → restore Primary Resource

• Neo Rune + Tec Rune Avoid damage for 5s → deal damage → generate 300 Offering → trigger Earthquake

• Neo Rune + Ton Rune Avoid damage for 5s → deal damage → generate 300 Offering → trigger Meteorites

• Neo Rune + Tal Rune Avoid damage for 5s → deal damage → generate 300 Offering → trigger Pestilent Swarm

• Neo Rune + Thul Rune Avoid damage for 5s → deal damage → generate 300 Offering → trigger Frost Nova

• Neo Rune + Tun Rune Avoid damage for 5s → deal damage → generate 300 Offering → trigger Stun Grenades

• Neo Rune + Teb Rune Avoid damage for 5s → deal damage → generate 300 Offering → trigger Iron Maiden

• Neo Rune + Xal Rune Avoid damage for 5s → deal damage → generate 300 Offering → gain Max Life

• Neo Rune + Que Rune Avoid damage for 5s → deal damage → generate 300 Offering → trigger Earthen Bulwark

• Neo Rune + Ner Rune Avoid damage for 5s → deal damage → generate 300 Offering → trigger Concealment

• Neo Rune + Ceh Rune Avoid damage for 5s → deal damage → generate 300 Offering → trigger Bone Spirit

• Neo Rune + Mot Rune Avoid damage for 5s → deal damage → generate 300 Offering → trigger Poison Creeper

• Neo Rune + Kry Rune Avoid damage for 5s → deal damage → generate 300 Offering → trigger Blood Surge

How to Buy Neo Rune from MMOJUGG

Step 1: Add Neo Rune to your cart and register a free MMOJUGG account to unlock up to 5% off. Use promo code mmojugg at checkout for an additional 5% discount. Select your game mode (Season, Season HC, Standard, Hardcore), enter your character name and Battletag, then complete your purchase.

Step 2: Our delivery team will send you a friend request in-game and arrange a secure face-to-face trade. Most orders are fulfilled within 10–60 minutes. Please verify the item contents before confirming receipt.

Why Choose MMOJUGG for Neo Rune

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