Path of Exile 2 The Greatwolf's Rune of Willpower

The Greatwolf's Rune of Willpower is a high-tier Socketable Item in Path of Exile 2, designed to support mana-based defenses by redirecting a portion of incoming damage to mana before life. When socketed into a Body Armour, it causes 10% of damage to be taken from mana before life. Once socketed, it cannot be removed, but it can be replaced with another rune or soul core.

Body Armour: 10% of Damage is taken from Mana before Life

The Greatwolf's Rune of Willpower Features

• Item Type: Socketable – Rune

• Function:

  • Body Armour: 10% of Damage is taken from Mana before Life

• Usable on: Body Armour

• Stack Size: 1 / 10  |  Drop Level: 65  |  Required Level: 50

How to Obtain The Greatwolf's Rune of Willpower

• Drop Locations:

  • Drops from enemies and chests in level 65+ zones

• Other Sources:

  • Not craftable directly

The Greatwolf's Rune of Willpower Crafting Synergy & Usage

The Greatwolf's Rune of Willpower is ideal for builds that rely on mana as a secondary defense layer. It synergizes well with gear and passives that increase mana pool, mana regeneration, and mana recovery on damage taken.

• Best Use Cases:

  • Spellcaster builds with large mana pools

  • Hybrid energy shield-mana defense setups

  • Builds using Mind Over Matter or similar mechanics

• Crafting Notes:

  • Must be socketed into gear with open Rune sockets

  • Cannot be removed once applied

  • Can be replaced with another rune or soul core since Patch 0.2.0 Dawn of the Hunt

The Greatwolf's Rune of Willpower FAQs

How does this rune interact with Mind Over Matter and similar mechanics?

It stacks additively with Mind Over Matter, allowing more damage to be redirected to mana. This can significantly improve survivability for builds with high mana pools.

What happens if my mana is depleted when damage is redirected?

If your mana is insufficient, the redirected damage will overflow to life. Maintaining mana sustain is crucial to maximize the rune's effectiveness.

Can this rune be used effectively with Energy Shield builds?

Yes. Hybrid builds that combine Energy Shield and mana-based mitigation benefit greatly, especially when paired with Eldritch Battery or similar passives.

Does this rune help mitigate damage-over-time effects?

Yes. The redirection applies to all damage types, including DoTs, making it useful against chaos damage, burning, and bleeding effects.

Is this rune viable in boss fights or high-damage encounters?

Absolutely. In encounters with burst damage, redirecting a portion to mana can prevent one-shot deaths and improve overall survivability.

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