Path of Exile 2 Greater Inspiration Rune

Greater Inspiration Rune is a high-tier Socketable item in Path of Exile 2, designed to maximize mana recovery for advanced builds. It offers superior bonuses compared to its lesser and standard counterparts, making it ideal for endgame scenarios where mana efficiency is critical. Once socketed, it cannot be removed, but it can be replaced with another rune or soul core.

Martial Weapons: Gain 24 Mana per Enemy Killed

Armour: 18% increased Mana Regeneration Rate

Wand or Staff: 24% increased Mana Regeneration Rate

Greater Inspiration Rune Features

• Item Type: Socketable – Rune

• Function:

  • Martial Weapons: Gain 24 Mana per Enemy Killed

  • Armour: 18% increased Mana Regeneration Rate

  • Wand or Staff: 24% increased Mana Regeneration Rate

• Usable on: Martial Weapons, Armour, Wands, or Staff

• Stack Size: 1 / 10  |  Drop Level: 62  |  Required Level: 30

How to Obtain Greater Inspiration Rune

• Drop Locations:

  • Found as world drops in zones level 62+

• Other Sources:

  • Crafted via Three to One Reforge recipe at the Reforging Bench

    • Recipe: Inspiration Rune x3 → Greater Inspiration Rune x1

Greater Inspiration Rune Crafting Synergy & Usage

Greater Inspiration Rune is ideal for endgame builds that demand high mana throughput and minimal downtime. It supports elite playstyles and scales well with high-frequency casting and kill-based triggers.

• Best Use Cases:

  • Melee builds that rapidly dispatch enemies and require strong mana sustain

  • Armor-based characters needing top-tier passive regeneration

  • Spellcasters with extreme mana consumption and continuous casting

• Crafting Notes:

  • Must be socketed into gear with open Rune sockets

  • Cannot be removed once applied

  • Can be replaced with another rune or soul core since Patch 0.2.0 Dawn of the Hunt

Greater Inspiration Rune FAQs

How does Greater Inspiration Rune compare to Inspiration Rune?

It offers significantly stronger bonuses across all gear types, making it optimal for endgame and mana-intensive builds.

Can I overwrite a socketed Greater Inspiration Rune?

Yes. Socketing another rune or soul core will destroy the original and apply the new effect.

Does the kill-based mana gain work with AoE or DoT skills?

Yes, as long as the enemy is killed by your character, the effect triggers regardless of skill type.

Can I use multiple Greater Inspiration Runes in one item?

Yes, provided the item has multiple Rune sockets. Effects stack linearly.

Is the rune tradable or stackable?

Yes. Stack size is 1 / 10 and it can be traded freely.

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• Step 1: Add Greater Inspiration Rune to your cart. Click "Proceed to Checkout" to fill in your delivery information.

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