Path of Exile 2 Courtesan Mannan's Rune of Cruelty

Courtesan Mannan's Rune of Cruelty is a high-tier Socketable Item in Path of Exile 2, designed to enhance ailment-based builds by increasing the magnitude of damaging ailments. When socketed into Gloves, it grants 15% increased Magnitude of Damaging Ailments you inflict. Once socketed, it cannot be removed, but it can be replaced with another rune or soul core.

Gloves: 15% increased Magnitude of Damaging Ailments you inflict

Courtesan Mannan's Rune of Cruelty Features

• Item Type: Socketable – Rune

• Function:

  • Gloves: 15% increased Magnitude of Damaging Ailments you inflict

• Usable on: Gloves

• Stack Size: 1 / 10  |  Drop Level: 65  |  Required Level: 50

How to Obtain Courtesan Mannan's Rune of Cruelty

• Drop Locations:

  • Drops from enemies and chests in level 65+ zones

• Other Sources:

  • Not craftable directly

Courtesan Mannan's Rune of Cruelty Crafting Synergy & Usage

Courtesan Mannan's Rune of Cruelty is ideal for builds that rely on damaging ailments such as Bleed, Poison, and Ignite. Increasing the magnitude of these ailments improves their effectiveness in dealing sustained damage over time.

• Best Use Cases:

  • DoT-focused builds that scale Bleed, Poison, or Ignite

  • Bow builds with high attack speed and ailment stacking

  • Bossing builds that rely on prolonged damage uptime

• Crafting Notes:

  • Must be socketed into Gloves with open Rune sockets

  • Cannot be removed once applied

  • Can be replaced with another rune or soul core since Patch 0.2.0 Dawn of the Hunt

Courtesan Mannan's Rune of Cruelty FAQs

Which builds benefit most from increased damaging ailment magnitude?

Bleed bow builds, Poison build, and Ignite build that rely on stacking or amplifying damage over time effects.

Does this rune affect non-damaging ailments like Chill or Shock?

No. It only affects damaging ailments such as Bleed, Poison, and Ignite.

Can this rune help trigger conditional effects like “Enemies take increased damage while Ignited"?

Yes. By increasing Ignite magnitude, you can meet higher thresholds for conditional bonuses and debuffs tied to ailment strength.

Is this rune useful in solo play or only in party support builds?

Primarily solo. Damaging ailments are typically self-applied and scale with personal gear and passives.

Does it synergize with critical strikes or ailment duration?

Yes. Critical strikes can apply stronger ailments, and increased magnitude enhances their damage. Duration scaling further boosts total damage output.

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